Professor of Entomology. He received a B.S. in Biochemistry from Michigan State University, a MS in Entomology (minor in Neurobiology) from Michigan State University and a Ph.D. in Entomology from the University of California, Riverside. He joined the Cornell faculty after postdoctoral study at the University of California, Berkeley. He is a member of the graduate fields of Entomology, Genetics and Development, and Environmental Toxicology. He received the Prominent Achievement Award from the Pesticide Science Society of Japan in 1996 and is a Member of Editorial Board for Pesticide Biochemistry and Physiology.
Our research is characterized by the four major areas below and seeks answers to both applied and basic questions. The techniques we use are varied and wide ranging.
Insecticide resistance and evolutionary biology. Resistance is one of the major problems facing public health and agriculture. Resistance has been referred to as "instant evolution" and causes major disruption whenever vectors of human disease or pests of agriculture can no longer be controlled. We study resistance as both a problem for which we need practical solutions, as well as an intensely interesting problem in basic evolutionary biology. We specialize in investigating the mechanisms (biochemical and genetic), inheritance, management, fitness costs and population genetics of insecticide resistance.
Insect genetics and molecular biology are active areas of research in our laboratory. We examine the genetic control and linkage of important traits (such as insecticide resistance), and we are now investigating the functions of a new gene repressor in insects which was recently identified by our group. We have also identified the recent "invasion" of a unique type of sex determination system in house fly populations in New York (male factor has moved to an autosome). The reason for the increasing frequency of this type of sex determination is one of many unanswered questions.
Sex determination in house flies is studied to better understand the factors responsible for the differences in the linkage of the male determining factor in field populations. R. Hamm recently discovered that 100% of male house flies in Florida are autosomal males (M is on autosome 3) and 100% of the males in Maine are Y males. Her dissertation research is aimed at better understanding this phenomenon.
Insecticide toxicology and metabolism studies are carried out to better understand the target sites of current and novel insecticides, as well as their pharmacodynamics (movement and fate within the organism). Studies have involved neuophysiological investigations into insecticide action as well as efforts to identify the enzymes involved in the metabolism of the insecticide.
Awards and Honors
- Cornell University Class Councils Faculty Award (2015) Cornell University Class Councils
- Fellow (2013) Entomological Society of America
- Graduate Student Selected Seminar Speaker (2012) Iowa State Univ.
- Recognition Award in Insect Physiology, Biochemistry and Physiology (2012) Entomological Society of America
- Sun, H., Kasai, S., & Scott, J. G. (2017). Two novel house fly Vssc mutations, D600N and T929I, give rise to new insecticide resistance alleles. Pesticide Biochemistry & Physiology. 143:116-121.
- Sun, H., Buchon, N., & Scott, J. G. (2017). Mdr65 decreases toxicity of multiple insecticides in Drosophila melanogaster. Insect Biochemistry and Molecular Biology. 89:11-16.
- Kasai, S., Sun, H., & Scott, J. G. (2017). Evolution of pyrethroid resistance in Musca domestica. Pest Management Science. 73:716-722.
- Kasai, S., Sun, H., & Scott, J. G. (2017). Diversity of knockdown resistance alleles in a single house fly population facilitates adaptation to pyrethroid insecticides. Insect Molecular Biology. 26:13-24.
- Smith, L. B., Kasai, S., & Scott, J. G. (2016). Pyrethroid resistance in Aedes aegypti and Aedes albopictus: important mosquito vectors of human diseases. Pesticide Biochemistry & Physiology. 133:1-12.
- Meisel, R. P., Davey, T., Son, J. H., Gerry, A. C., Shono, T., & Scott, J. G. (2016). Is multifactorial sex determination in the house fly, Musca domestica (L.), stable over time? Journal of Heredity. 107:615-625.
- Sun, H., Tong, K. P., Kasai, S., & Scott, J. G. (2016). Overcoming super-kdr mediated resistance: Multi-halogenated benzyl pyrethroids are more toxic to super-kdr than kdr house flies. Insect Molecular Biology. 25:126-137.
- San Miguel, K., & Scott, J. G. (2016). The next generation of insecticides: dsRNA is stable as a foliar applied insecticide. Pest Management Science. 72:801–809.
- Sun, H., Tong, K. P., Kasai, S., & Scott, J. G. (2015). Overcoming super-knock down resistance (super-kdr) mediated resistance: multi-halogenated benzyl pyrethroids are more toxic to super-kdr than kdr house flies. Insect Molecular Biology.
- San Miguel, K., & Scott, J. G. (2015). The next generation of insecticides: dsRNA is stable as a foliar-applied insecticide. Pest Management Science.