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Philip Houtz

Philip Houtz

Advisor: Dr. Nicolas Buchon

Research Interests

I am a Ph. D student in Nicolas Buchon’s lab. I am using Drosophila melanogaster as a model to study the genetic networks that control epithelial turnover in the gut. Specifically, I am interested in the mechanisms that control enterocyte extrusion from the epithelial layer, how this cellular delamination is coordinated with cytokine signaling to induce appropriate proliferation and differentiation responses in intestinal stem cells, and how the activity of bacteria within the gut can disrupt or maintain these events. My work should provide new, detailed insight into the cellular events that are responsible for maintaining gut homeostasis and integrity, and how different bacterial interactions may shape these processes.